Drug Interactions With Gabapentin

If certain medications are combined, there is a potential for negative drug interactions. With gabapentin, these interactions can affect the levels of medication in your blood (which may reduce their effectiveness). They can also increase the risk for unwanted side effects. If drug interactions with gabapentin are a concern, your healthcare provider may adjust your dosages.

 

An Overview of Drug Interactions With Gabapentin

Gabapentin (Neurontin®) can potentially interact with a few other medications. Some of the medicines that may lead to drug interactions with gabapentin include:
 
  • Alcohol
  • Antacids containing aluminum or magnesium (such as Phillips'® Milk of Magnesia, Maalox®, or Gaviscon®)
  • Hydrocodone (Lortab®, Norco®, Vicodin®)
  • Morphine (Avinza®, MS Contin®, MSIR®, Oramorph SR®, Roxanol®)
  • Naproxen (Aleve®, Anaprox®, Naprelan®, Naprosyn®)
     

More Information on Gabapentin Interactions

The following sections explain in detail the potentially negative interactions that can occur when gabapentin is combined with any of the drugs listed above.
 
Alcohol
Alcohol can increase your risk of certain gabapentin side effects, such as drowsiness or dizziness. Talk to your healthcare provider about drinking alcohol while taking the drug (see Neurontin and Alcohol for more information).
 
Aluminum or Magnesium Antacids
Antacids that contain aluminum or magnesium can decrease the absorption of gabapentin into your body, perhaps making it less effective. In order to avoid this interaction, do not take these medications within two hours of each other.
(Drug Interactions With Gabapentin Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;