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Lidoderm Drug Interactions

When Class I arrhythmia medications or local anesthetics are taken with Lidoderm, drug interactions may occur. To help ensure a safe treatment process, make sure your healthcare provider is aware of any other medications you are taking, including nonprescription medicines, vitamins, and herbal supplements, before starting treatment with the Lidoderm patch.

An Overview of Interactions With Lidoderm

Even though the Lidoderm® patch (lidocaine patch) is applied to the skin, it can potentially interact with several other medications (as some of the medication is absorbed into the bloodstream). Some of these medicines that may lead to drug interactions with Lidoderm include:
  • Local anesthetics (any anesthetics applied or injected in order to achieve pain relief or numbness in a specific area), such as those used in dental procedures.

Lidoderm Drug Interactions Explained

The following sections offer more details on combining Lidoderm with any of the drugs listed above.
Class I Antiarrhythmics
In addition to its use as an anesthetic, lidocaine (the active ingredient in Lidoderm) is also an arrhythmia medication. Caution should be used if Lidoderm is combined with other similar arrhythmia medications (especially Class I arrhythmia medications).
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